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Operating Margin for Alnylam Pharmaceuticals (ALNY)

As of · Reported

Metric

TTM

17.5%

YoY change

+21.37pp

Trough year (2018)

-1087.6%

Peak year (2025)

13.5%

Operating Margin history chart for Alnylam Pharmaceuticals (ALNY) from 2004 to 2025

Latest: 13.5%

Operating Margin change chart for Alnylam Pharmaceuticals (ALNY) from 2004 to 2025

Latest: +21.37pp

Operating Margin history table for Alnylam Pharmaceuticals (ALNY) from 2004 to 2025

  • 202513.5%+21.37pp
  • 2024-7.9%+7.57pp
  • 2023-15.4%+60.24pp
  • 2022-75.7%+8.26pp
  • 2021-83.9%+84.16pp
  • 2020-168.1%+259.41pp
  • 2019-427.5%+660.06pp
  • 2018-1087.6%-531.37pp
  • 2017-556.2%+344.13pp
  • 2016-900.3%-180.06pp
  • 2015-720.3%+80.71pp
  • 2014-801.0%-603.92pp
  • 2013-197.0%-3.03pp
  • 2012-194.0%-127.77pp
  • 2011-66.2%-22.19pp
  • 2010-44.1%+3.80pp
  • 2009-47.9%-18.91pp
  • 2008-28.9%+154.12pp
  • 2007-183.1%-36.39pp
  • 2006-146.7%+613.85pp
  • 2005-760.5%-6.35pp
  • 2004-754.2%—

Operating Margin values are taken from Alnylam Pharmaceuticals's reported income statements (quarterly 10-Q and annual 10-K filings with the U.S. Securities and Exchange Commission). Each row shows the period end date and the filing date. YoY compares each figure to the same period one year earlier. Amounts are in USD as filed.

About Operating Margin at Alnylam Pharmaceuticals (ALNY)

According to Alnylam Pharmaceuticals's latest reported financial statements, the company's latest reported operating margin is 17.5%. Operating margin is operating income divided by revenue — the share of each sales dollar left after cost of goods sold and operating expenses (SG&A, R&D), but before interest and taxes. It isolates how profitable the core business is before financing and tax decisions, so it is comparable across companies with different capital structures.

Headline figure above is from the reporting period ending (reported ). Chart and table below cover the full reported history back to .

In 2025, Alnylam Pharmaceuticals (ALNY) operating margin totalled 13.51% – expanded 21.4 percentage points year-over-year.

2025 marks the peak operating margin at 13.51%, with the historical low of -1087.56% recorded in 2018.

Alnylam Pharmaceuticals Operating Margin by Year

Alnylam Pharmaceuticals Operating Margin 2025: 13.5%

In 2025, Alnylam Pharmaceuticals reported operating margin of 13.51%, expanded 21.4 percentage points from 2024. This figure represents the highest annual value in the available history.

Alnylam Pharmaceuticals Operating Margin 2024: -7.9%

Alnylam Pharmaceuticals operating margin in 2024 was -7.87%, expanded 7.6 percentage points from 2023.

Alnylam Pharmaceuticals Operating Margin 2023: -15.4%

2023's operating margin for Alnylam Pharmaceuticals came in at -15.43%, expanded 60.2 percentage points from 2022.

Alnylam Pharmaceuticals Operating Margin 2022: -75.7%

Alnylam Pharmaceuticals posted operating margin of -75.68% in 2022, expanded 8.3 percentage points from 2021.

Alnylam Pharmaceuticals Operating Margin 2021: -83.9%

Alnylam Pharmaceuticals operating margin in 2021 was -83.93%.

See more financial history for Alnylam Pharmaceuticals (ALNY).

Sector peers by Operating Margin

Healthcare peers of Alnylam Pharmaceuticals (ALNY), ranked by their latest operating margin

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