Question 1

What is Vertex Pharmaceuticals's P/B ratio?

Accepted Answer

Vertex Pharmaceuticals (VRTX) P/B ratio is 5.9× as of June 5, 2026. The ratio is calculated by dividing market capitalisation by book value of equity, using USD-normalised financials (IAS 21 exchange-rate translation for non-USD reporters).

Question 2

How is the P/B ratio calculated?

Accepted Answer

P/B = Market Capitalisation ÷ Book Value of Equity (most recent quarterly shareholders' equity), or equivalently Share Price ÷ Book Value Per Share. All inputs are sourced from audited GAAP/IFRS filings and translated to USD using period-end exchange rates so the multiple is comparable across companies and currencies.

Question 3

What is the P/B ratio?

Accepted Answer

The price-to-book (P/B) ratio compares a company's market capitalisation to its book value of equity (total shareholders' equity) on the most recent quarterly balance sheet. It is calculated as market cap ÷ book value of equity (equivalent to share price ÷ book value per share). A P/B below 1× implies the market values the business below its accounting net worth; values well above 1× reflect intangible assets, brand value, or a high return on equity.

Question 4

What is a good P/B ratio for Vertex Pharmaceuticals?

Accepted Answer

A "good" P/B depends on the business model. Banks, insurers, and other capital-heavy financials typically trade near 1×; asset-light technology and consumer-brand companies can sustainably trade at 5×+ because much of their value is intangible. P/B is most informative when paired with return on equity (ROE). For Vertex Pharmaceuticals specifically, the relevant sector benchmark is the current sector median of 3.4×.

Question 5

Is Vertex Pharmaceuticals's P/B ratio high or low?

Accepted Answer

Vertex Pharmaceuticals's P/B ratio of 5.9× is below its own 5-year average of 6.1× and above the sector median of 3.4×. That places the current reading at the 26th percentile of its 10-year history. A higher multiple usually reflects stronger expected growth, lower perceived risk, or higher returns on capital; a lower multiple reflects the opposite.

Question 6

What is Vertex Pharmaceuticals's historical P/B ratio range?

Accepted Answer

In the available daily series, Vertex Pharmaceuticals (VRTX) P/B ratio has ranged from a low of 2.1× in 2003 to a high of 34.6× in 2011. The 5-year average is 6.1× and the 5-year median is 5.9×.

Question 7

What was Vertex Pharmaceuticals's P/B ratio in 2025?

Accepted Answer

Vertex Pharmaceuticals (VRTX) P/B ratio at the end of 2025 was 6.2×. Annual values reflect the multiple on the last trading day of each calendar year, using the trailing twelve-month book value figure available at that date.

Question 8

Why does Vertex Pharmaceuticals's P/B ratio change over time?

Accepted Answer

Valuation multiples move with two inputs: the numerator (market capitalisation, which tracks the share price) and the denominator (book value). Share-price changes — driven by interest rates, earnings expectations, risk appetite, and broader market sentiment — typically dominate short-term moves, while changes in the underlying fundamental drive the longer-term trend. As a result, the ratio can rise during stock-price rallies even if the business itself has not become more valuable, and fall during sell-offs even when fundamentals are improving.


2025	$115.11B	$18.67B	6.2×	-0.2×	Dec 31, 2025
2024	$103.70B	$16.41B	6.3×	+0.4×	Dec 31, 2024
2023	$104.86B	$17.58B	6.0×	+0.6×	Dec 31, 2023
2022	$74.19B	$13.91B	5.3×	-0.2×	Dec 31, 2022
2021	$55.91B	$10.10B	5.5×	-1.5×	Dec 31, 2021
2020	$61.46B	$8.69B	7.1×	-2.2×	Dec 31, 2020
2019	$56.49B	$6.09B	9.3×	-0.2×	Dec 31, 2019
2018	$42.23B	$4.44B	9.5×	-9.1×	Dec 31, 2018
2017	$37.70B	$2.03B	18.6×	+2.9×	Dec 31, 2017
2016	$18.08B	$1.16B	15.6×	-16.4×	Dec 31, 2016
2015	$30.13B	$939.97M	32.1×	+5.8×	Dec 31, 2015
2014	$28.26B	$1.08B	26.3×	+13.6×	Dec 31, 2014
2013	$17.18B	$1.36B	12.7×	+3.7×	Dec 31, 2013
2012	$8.99B	$999.18M	9.0×	+0.2×	Dec 31, 2012
2011	$6.91B	$786.84M	8.8×	-5.2×	Dec 31, 2011
2010	$7.05B	$503.97M	14.0×	+6.2×	Dec 31, 2010
2009	$8.52B	$1.10B	7.8×	-11.2×	Dec 31, 2009
2008	$4.52B	$238.87M	18.9×	+7.7×	Dec 31, 2008
2007	$3.04B	$271.30M	11.2×	+2.0×	Dec 31, 2007
2006	$4.64B	$505.94M	9.2×	-3.3×	Dec 31, 2006
2005	$2.97B	$239.18M	12.4×	-11.2×	Dec 31, 2005
2004	$835.82M	$35.44M	23.6×	+19.4×	Dec 31, 2004
2003	$804.88M	$192.84M	4.2×	+1.0×	Dec 31, 2003
2002	$1.21B	$378.58M	3.2×	-0.7×	Dec 31, 2002
2001	$1.84B	$475.35M	3.9×	—	Dec 31, 2001


Quest Diagnostics (DGX)	2.9×
Moderna (MRNA)	2.7×
Charles River (CRL)	2.6×
Regeneron Pharmaceuticals (REGN)	2.6×
Henry Schein (HSIC)	2.5×
Labcorp Holdings (LH)	2.5×
Danaher (DHR)	2.4×
UnitedHealth Group (UNH)	2.4×
Solventum (SOLV)	2.3×
Becton, Dickinson and (BDX)	1.8×
Pfizer (PFE)	1.8×
Molina Healthcare (MOH)	1.7×
Cigna (CI)	1.7×
Waters Corporation (WAT)	1.6×
Cooper Companies (COO)	1.5×
Elevance Health (ELV)	1.5×
Universal Health Services (UHS)	1.5×
Biogen (BIIB)	1.4×
Baxter International (BAX)	1.4×
Revvity (RVTY)	1.4×
Zimmer Biomet Holdings (ZBH)	1.2×
CVS Health (CVS)	1.2×
Humana (HUM)	1.1×
Viatris (VTRS)	1.1×
Centene (CNC)	0.8×

P/B Ratio for Vertex Pharmaceuticals (VRTX)

P/B Ratio daily chart for Vertex Pharmaceuticals (VRTX)

Historical P/B Ratio for Vertex Pharmaceuticals (VRTX) from 2001 to 2025

About P/B Ratio at Vertex Pharmaceuticals (VRTX)

Vertex Pharmaceuticals P/B Ratio by Year

Vertex Pharmaceuticals P/B Ratio 2025: 6.2×

Vertex Pharmaceuticals P/B Ratio 2024: 6.3×

Vertex Pharmaceuticals P/B Ratio 2023: 6.0×

Vertex Pharmaceuticals P/B Ratio 2022: 5.3×

Vertex Pharmaceuticals P/B Ratio 2021: 5.5×

Sector peers by P/B Ratio — chart

Sector peers by P/B Ratio — table

Frequently asked questions

Vertex Pharmaceuticals (VRTX) Key Financials

P/B Ratio daily chart for Vertex Pharmaceuticals (VRTX)

Historical P/B Ratio for Vertex Pharmaceuticals (VRTX) from 2001 to 2025

About P/B Ratio at Vertex Pharmaceuticals (VRTX)

Vertex Pharmaceuticals P/B Ratio by Year

Vertex Pharmaceuticals P/B Ratio 2025: 6.2×

Vertex Pharmaceuticals P/B Ratio 2024: 6.3×

Vertex Pharmaceuticals P/B Ratio 2023: 6.0×

Vertex Pharmaceuticals P/B Ratio 2022: 5.3×

Vertex Pharmaceuticals P/B Ratio 2021: 5.5×

Sector peers by P/B Ratio — chart

Sector peers by P/B Ratio — table

Frequently asked questions

+What is Vertex Pharmaceuticals's P/B ratio?

+How is the P/B ratio calculated?

+What is the P/B ratio?

+What is a good P/B ratio for Vertex Pharmaceuticals?

+Is Vertex Pharmaceuticals's P/B ratio high or low?

+What is Vertex Pharmaceuticals's historical P/B ratio range?

+What was Vertex Pharmaceuticals's P/B ratio in 2025?

+Why does Vertex Pharmaceuticals's P/B ratio change over time?

Vertex Pharmaceuticals (VRTX) Key Financials